Program

Scheduled Abstracts by Division
Biological and Medicinal Chemistry
Monday AM
BM1
202
Advances in Nucleic Acid Chemistry and Technology
Organizer(s) - Yingfu Li and Juewen Liu
Chair(s) - Juewen Liu
08:00
Enzyme-powered Three Dimensional DNA Nanomachine for DNA Walking, Payload Release, and Biosensing $*Li F, Yang X, Tang Y, Mason SD, Yu Z
08:20
The Development of Isothermal Amplification in Biosensors Lou XD, $*Xia F
08:40
A Catalytic DNA Probe Activated by a Specific Strain of Bacterial Pathogen $*Li Y, Shen Z, Wu Z, Chang D, Zhang W, Tram K, Lee C, Salena B, Kim P
09:00
One-step, for Multiplexed Detection of DNA/RNA in Crude Samples Using Microfluidic Chips $*Jiang X
09:20
Aptamers Binding to Microbial Phogens Hamula CLA, Liu YM, Newbigging AM, Peng HY, Wang ZX, Tyrrell GJ, Li X-F, $*Le XC
10:00
 
Coffee Break
10:20
Aptamers and Other Oligonucleotide-based Systems: New Uses and Designs $*Stojanovic M
11:00
Litmus Test for Uranyl Using an RNA-cleaving DNAzyme Manochehry SE, Tram KQ, *Li Y
11:20
 
End of Session
BM3
305
Enzymes: Mechanism, Function, and Structure
Organizer(s) - Stephen Bearne
Chair(s) - Stephen Bearne, Andrew Bennet
08:20
Transition State Structure in the Design of Drug Candidates $*Schramm VL
09:00
Engineering Enzymes to Manipulate Cell-surface Glycan Structure $*Kwan DH, Constantinescu I, Ernst S, Bailleul G, Soroko M, Yu CC, Withers SG, Kizhakkedathu J, Samain E, Boraston A
09:20
Omega-6 Epoxy Eicosatrienoic Acids (EETs) Metabolize by Cyclooxygenases (COX) to Yield Proangiogenic Metabolites Rand A, Barnych B, Cajka T, Lee K, Fiehn O, $Hammock B
09:40
 
Coffee Break
10:20
Ring Strain and Mechanism-based Covalent Inhibitors $*Bennet AJ, Sannikova N, Ferran-Dai M, Sannikov O
10:40
The Inhibition of Cell Shape-determining Enzymes in Helicobacter pylori Liu Y, Soni A, $*Tanner ME
11:20
 
End of Session
BM7
203
Natural Products - Joint with OR
Organizer(s) - Russell Kerr
Chair(s) - Russell Kerr
08:00
Understanding Programming of Fungal Iterative Polyketide Synthases $*Vederas JC
08:40
One Niche, One Bacterium, Many Natural Products *Ruzzini AC, Van Arnan EB, Sit CS, Ramadhar TR, Currie CR, $Clardy J
09:00
Characterisation and Biological Evaluation of Jadomycins Produced in a Ne-trifluoroacetly-L-lysine Production with Streptomyces venezuelae Forget SM, $*Jakeman DL
09:20
The Annotation of Novel Polyketide Synthase Genes in the Lichen Caldonia uncialis Abdel-Hameed M, Bertrand R, $*Sorensen JL
09:40
Wireworm Control by Buckwheat - A Metabolomic Investigation $*Kirby CW, Nabuurs MH, McCallum JL, McKenzie DB, Noronha C
10:00
 
Coffee Break
10:20
Taking a Closer Look at Phytoplankton Interactions with Heterotrophic Bacteria: Basic Science Complementing Discovery of Pharmacologically Relevant Metabolites $*Mincer TJ, Whalen KE, Flynn-Carroll A
11:00
Discovery of Novel Microbial Peptide Natural Products Using a Metabolomics Screening Approach and Insights into the Biosynthesis *Gill KA, Berrue F, Haltli B, $Kerr RG
11:20
 
End of Session
BM4
Meeting Room 4
General Biological and Medicinal Chemistry
Organizer(s) - Stephen Bearne
Chair(s) - Stephen Bearne, David Jakeman
08:00
A Fluorescent Sensor and Gel Stain for the Detection of Pyrophosphorylated Proteins Williams FJ, $Fiedler D
08:20
Conjugation of Prodigiosenes to Bioactive Molecules: Synthesis and Anticancer Activity Investigation Figliola C, Marchal E, *Thompson A
08:40
Antimicrobial Applications of a Supramolecular System Gravel J, $*Schmitzer A
09:00
Antifungal Compounds with Diverse Activity Profiles from a Bacterial Symbiont of a Fungus-growing Ant Sit CS, Van Arnam EB, Ruzzini AC, $*Clardy J, Currie CR
09:20
Selective Fluorination of the Pyridine Benzylic Positions with N-fluorobenzenesulfonimide Meanwell M, Nodwell M, Rainer M, $*Britton R
09:40
Development of Ruthenium(II) Polypyridyl Complexes Containing p-expansive Functional Ligands as Photosensitizers for Photodynamic Therapy Sainuddin T, $McFarland M, Monro S, *Yin H, Hetu M
10:00
 
Coffee Break
10:20
On-demand Bone Regeneration Using Ultrasound-triggered Nanocomplexes for Delivery of BMP-2 Crasto GJ, Kartner N, $Manolson MF, Peel SAF
10:40
Peptidomimetic GHSR-1a Agonists as PET Imaging Agents for Prostate Cancer Lalonde T, Fowkes M, Dhanvantari S, Kovacs MS, $*Luyt LG
11:00
Discovery and Characterization of Potent Diphenylureas versus Methicillin- and Vancomycin-resistant Staphylococcus aureus Hassan I, $*Moustafa MM, Mohammad H, Seleem M, Mayhoub A
11:20
 
End of Session
Monday PM
BM1
202
Advances in Nucleic Acid Chemistry and Technology
Organizer(s) - Yingfu Li and Juewen Liu
Chair(s) - Yingfu Li, Chris Le
14:00
DNA as a Catalyst $*Silverman SK
14:40
Three Na+-specific RNA-cleaving DNAzymes $*Liu J, Zhou W, Huang PJJ
15:00
Understanding Ligand Binding by the Cocaine-binding Aptamer Slavkovic S, Neves MAD, Churcher ZR, $*Johnson PE
15:20
In Vitro Selection of a Silver-specific DNAzyme and its Application for Ag+ Detection Saran R, $*Liu J
15:40
Insights into Aptamer Selection Parameters and Characterization Workflow $*DeRosa MC, McKeague M, DeGirolamo A
16:00
 
Coffee Break
16:20
Findings from in vitro Selection (SELEX) that Throw Light on Surprising and Fundamental Properties of DNA and RNA $*Sen D, Shumayrikh N, Barlev A, Einarson O
17:00
DNA Photoreactivation by DNA: The UV1C DNAzyme Catalyzes Repair over Formation of Cyclobutane Thymine Dimers Using 305 nm Light Barlev A, *Sekhon G, $Sen D
17:20
One-pot, Solvent-free Synthesis of Novel Pyridodipyrimidine Derivatives: Their Anticancer Activity against HeLa Human Cervical Cancer Cell Line Aremu OS, *koorbanally NA, Singh M, Singh P, Chunderika M
17:40
 
End of Session
BM3
200C1
Enzymes: Mechanism, Function, and Structure
Organizer(s) - Stephen Bearne
Chair(s) - Stephen Bearne, Andrew Bennet
14:00
Kanosamine Biosynthesis Enzymes Have Co-evolved to Process an Unstable Intermediate $*Palmer DRJ, Vetter ND
14:40
Development of Reversible Tissue Transglutaminase Inhibitors with Increased Resistance to Glutathione Addition Apperley KYP, Roy I, $*Keillor JW
15:00
How the Glycosyltransferase OGT Catalyzes Amide Bond Cleavage Janetzko J, Trauger SA, Lazarus MB, Jiang J, $*Walker S
15:20
Membrane Binding and Phosphlipid Transfer Ability of Yeast Sec14, Sec14 Homologs, and Human Phosphatidylinositol Transfer Proteins PITPa and b $*Atkinson J, Panagabko C, Baptist M
15:40
Inhibition and Conformational Modulation of Tissue Transglutaminase $*Keillor JW, Akbar A, Clouthier C
16:00
 
Coffee Break
16:20
Detection of in vivo Enzyme Activiy with catalyCEST MRI $*Pagel MD, Sinharay S, Fernandez-Cuervor G, Daryaei I
16:40
Structural Insight into the Substrate Specificity of the hOgg1 DNA Repair Enzyme Sowlati-Hashjin S, *Wetmore S
17:00
Computational Insights Into Pre-transfer Editing in Threonyl tRNA Synthetase (ThrRS) Gauld JW
17:40
 
End of Session
BM7
203
Natural Products - Joint with OR
Organizer(s) - Russell Kerr
Chair(s) - Chris Boddy
14:00
Universal Characterization of Natural Product Libraries: Promise for Future Biomedical Applications $*Linington RG
14:40
A Bio-inspired Platform for the Synthesis of Lignan Natural Products $Lumb JP
15:00
Exploring Natural Product Biosynthesis in Gram-negative Bacteria $Findlay B
15:20
Genome Mining of Marine Proteobacteria Using Direct Cloning Methods $Ross AC
16:00
 
Coffee Break
16:20
Big Data for Microbial Small Molecules $*Magarvey NA
17:00
Biosynthesis Gene Clusters: Nature's Gift to Chemical Discovery and Application $*Moore B
17:40
 
End of Session
Tuesday AM
BM1
202
Advances in Nucleic Acid Chemistry and Technology
Organizer(s) - Yingfu Li and Juewen Liu
Chair(s) - Scott Silverman, Juewen Liu
08:00
Towards Nucleic Acid Labelling with the Inverse Electron Demand Diels-Alder Reaction Eljabu F, Yalagala R, *Yan T
08:20
Development and Application of Novel Methods for Quantitative Detection of Circulating miRNAs in Biological Samples Yin B-C, Ma J-L, $*Ye B-C
08:40
Fabrication of High-density RNA and Chemically-modified Nucleic Acid Arrays for Protein and Aptamer Research $*Damha MJ, Lietard J, Pavlic A, Somoza MM
09:20
Metal Modified DNA Double Crossover Molecules Rousina-Webb A, Toader V, $*Sleiman HF
09:40
Targeting Cancer Stem Cell In Vivo Using RNA Aptamers $*Duan W, Shigdar S
10:00
 
Coffee Break
10:20
Combining Theory with Experiments to Attain Deeper Insight Into Ribozyme Mechanism $*Bevilacqua PC, Hammes-Schiffer S
11:00
Small Oligonucleotide Probes for Secondary Structure Probing and Competitive Displacement Based Ligand-binding Analysis of the Microcystin-LR Aptamer Walsh R, Perreault J
11:20
Short Protein Interacting DNAs and RNAs (SPDRs) Inhibit Phospholamban's Regulation of SERCA Activity Soller KJ, Jing M, Yang J, Veglia G, $*Bowser MT
11:40
Defining the Activated Species in a Heme-utilizing DNAzyme Shumayrikh N, *Sen D
12:00
A Synthetic DNA Probe for an Important Human Pathogen Feng Q, Tram K, Gu J, $Li Y, *Salena BJ
12:20
 
End of Session
BM3
200C1
Enzymes: Mechanism, Function, and Structure
Organizer(s) - Stephen Bearne
Chair(s) - Stephen Bearne, Andrew Bennet
08:00
Low-barrier Hydrogen Bonds in Enzyme Cooperativity Tittmann K
08:40
Novel Dual Inhibitors of Plasmodium falciparum M1 and M17 Metalloaminopeptidases at Potential Antimalarial Agents $*Scammells PJ, McGowan S, Vinh N, Drinkwater N
09:00
The Investigation of Structural Determinants that Mediate Selective Inhibition of UBA5, the UFM1 Activating Enzyme *Paiva S-L, da Silva SR, Bancerz M, Rosa D, Sina D, Rigby A, Ahmar S, Geletu M, Lewis AM, DeAraujo E, Chen J, Cai Y, Lukkarila JL, Li H, $Gunning PT
09:20
Comparing Empirical Kinetic Models with the Classical Mechanistic Enzyme Kinetic Approach Walsh R
09:40
Characterizing Archaeal Prephenate Dehydrogenases in Tyrosine Biosynthesis *Shlaifer I, $Turnbull JL
10:00
 
Coffee Break
10:40
Metal-dependent Inhibition of Wild Type KDO8PS by KDO8P Oxime Gama SR, $Berti PJ
11:00
A Search for Unnatural Biomimetic Catalysts MacDonald MJ, Bian S, Mogalisetti P, Walt DR, $Gellman SH
11:20
Inhibition of Racemases and Epimerases by Substrate-product Analogues *Bearne SL, Pal M
11:40
 
Teva Canada Limited Biological and Medicinal Chemistry Lectureship Award Lecture
11:40
The Bottomless Barrel of Fluorescent Protein-based Tools for Visualizing Biochemistry as it Happens $*Campbell RE
12:20
 
End of Session
BM7
203
Natural Products - Joint with OR
Organizer(s) - Russell Kerr
Chair(s) - Nathan Magarvey
08:00
The Screening Hypothesis: A Tool for Understanding and Predicting Activity of Thioesterase Domains from Polyketide and Non-ribosomal Peptide Biosynthesis $*Boddy CN
08:40
Natural Product Diversity from Fungi Isolated from Frobisher Bay in Canada's Arctic *Grunwald AL, Berrue F, Overy DP, $Kerr RG
09:00
Discovery and Detailed Structural Studies of Natural Products from Termite-associated Actinobacteria Ramadhar TR, Kim KH, Beemelmanns C, Cao S, Klassen J, Wyche TP, Hou Y, Poulsen M, Bugni T, Currie CR, $*Clardy J
09:40
Nannyberry (Viburnum lentago L.) Extracts Show Anti-cancer Effects in an in vitro Androgen-sensitive LNCaP Model of Prostate Cancer $*McCallum JL, Stetson CR, Kirby CW, Soolanayakanahally R, Schroeder WR, Hurta RAR
10:00
 
Coffee Break
10:20
A Common Platform for Antibiotic Dereplication and Adjuvant Discovery $*Wright GD
11:00
Coumarin Analogues and their Anti-a-glucosidase Activity Ayana R, McElrea A, Hollett J, $*Ata A
11:20
Isolation, Structural Characterization, and Preliminary Biological Activity of New Oximidine Compounds Nabuurs MH, Boyetchko S, McCallum JL, $*Kirby CW
11:40
 
End of Session
Tuesday PM
BM1
202
Advances in Nucleic Acid Chemistry and Technology
Organizer(s) - Yingfu Li and Juewen Liu
Chair(s) - Philip Johnson, Richard Manderville
14:00
Interaction between Single Strands of siRNA and Different Chemical Groups Giraud L, Viricel W, Chain J, Giasson S
14:20
Multivalent DNA Nanostructures to Improve Cellular Targeting Lacroix A, Conway JW, Edwardson TGW, *Fakhoury JJ, $Sleiman H
14:40
Influence of DNA Flexibility towards Human O6-alkylguanine-DNA Alkyltransferase Activity and Nucleotide Incorporation by a Translesion DNA Polymerase O'Flaherty DK, Guengerich FP, Egli M, $*Wilds CJ
15:00
The Development of Intrinsic Nucleoside Quencher Analogs of Thymidine and Cytidine $*Hudson RHE, Matarazzo A, Ettles C, Suchy M, Charles M, Moustafa M
15:20
DNA-templated Synthesis of Sequence-controlled RNA Amphiphiles Using a Combination of Enzymatic and Solid-phase Methods Dore MD, Fakhoury JJ, Bujold KE, $Sleiman HF
15:40
Utility of Fluorescent Guanine Mimics for Aptamer Binding to Ochratoxin A Fadock KL, *Manderville RA
16:00
 
Coffee Break
16:20
Phosphoramidate Modifications for Improved Biological Properties of Oligonucleotides Vlaho D, $*Damha MJ
16:40
G-register Exchange Dynamics in Guanine Quadruplexes Harkness R, $*Mittermaier A
17:00
Update on the Utility of Fluorescent Nucleobase Probes for Aptasensor Development *Manderville RA
17:20
Discovery of Adjacent Adenine as the Intramolecular Distal Species for Remarkable Activity Enhancement of G-quadruplex-hemin DNAzyme/RNAzyme $*Nie Z, Li W, Li Y, Liu ZL, Yao SZ
17:40
 
End of Session
BM2
200C1
Carbohydrates - Joint with OR
Organizer(s) - David Jakeman
Chair(s) - David Jakeman
14:00
The Production and Inhibition of the Biofilm Related Poly-N-acetylglucosamine Exopolysaccharide $*Nitz M
14:20
Elucidating the Biosynthetic Logic of Exopolysaccharide Phosphonate Tailoring $*Horsman GP
14:40
Towards 18F Labeled Conduritol Aziridines for PET Imaging b-glucocerebrosidase, a Potential Marker of Early Parkinson's Disease $*Phenix CP, Tesolin D, Adams BT, Nicolli S, Lees SJ, Chowdhury MA, Rempel BP
15:00
Human Neuraminidase Enzymes as a Target for the Development of New Anti-adhesives $*Cairo CW
15:20
Synthesis and Evaluation of Potential Vaccines against Lyme Disease Hagar M, Kirshenbaum M, Huchenski BS-N, Said H, Toutsenko S, Lee S, $*Grindley TB
15:40
Discovery and Synthesis of Vaccines Monteiro MA
16:00
 
End of Session
BM5
203
Medicinal Chemistry: A Canadian Tradition - Joint with OR
Organizer(s) - Jason Burch and Patrick Gunning
Chair(s) - Jason Burch and Patrick Gunning
14:20
 
IntelliSyn Pharma Research Excellence Award Lecture
14:20
Development of New Reactions for Natural Product Synthesis and Drug Discovery $*Britton RA
15:00
Synthesis and Characterization of Potent and Selective Inhibitors for Matriptase-2 St-Georges C, Désilets A, Dion SP, Boudreault PL, Najmanovich RJ, Leduc R, $*Marsault E
15:20
Keeping HIV Resistance in Check: The Discovery of Doravirine Ducharme Y
16:00
 
Coffee Break
16:20
Identification of Potent and Selective RORc Agonists and Inverse Agonists for the Orthogonal Modulation of Th17-cell Mediated Immune Responses *René O
17:00
Autoxidation and Microsomal Metabolism Leading to Quinone Formation in Secoisolariciresinol Analogues McGurn LDA, Asiamah I, Maloney K, Allen KJH, $*Krol ES
17:20
ortho-Quinone as Key Intermediate in Biologically Active Molecule Synthesis Huang Z, $*Lumb J-P
17:40
 
End of Session
BMP
Scotiabank Centre
Poster
From 17:40 until 19:30
17:40
N-demethylation of Alkaloids Using Nanoscale Zero-valent Iron Awalt JK, Singer RD
17:40
Biophysical Characterization of the Recently Discovered Peptide Hormone, Apela Huang SK, Shin K, Sarker M, $Rainey JK
17:40
Characterization of the Role of microRNAs in the Innate Antiviral Response Quan C, Singaravelu R, Srinivasan P, Roy DG, Servant MJ, $*Pezacki J
17:40
Activity-based Protein Profiling of the Role of miR-185 in the Immunometabolic Response to HCV Infection Filip R, Desrochers G, Pezacki JP
17:40
Trichloroethylidene Acetals Kirshenbaum M, $*Grindley TB
17:40
Synthesis and Evaluation of Molecular Imaging Probes to Study Voltage-gated Channels (Cav1.2) in Live Cells Araujo L, Kerkovius JJ, Nelson R, Beattie M, $*Menard F
17:40
Optimizing 19F-labelled Tryptophan to Probe Local Conformation, Dynamics, and Ligand Binding in a GPCR by NMR Spectroscopy Kenward C, Bekkers C, Shin K, Muzzaddid S, $Rainey J
17:40
Synthesis and Characterization of Cyclometalated Ruthenium(II) Complexes for Applications in Photoactivated Cancer Therapy McCain J, Sainuddin T, Yin H, Hetu M, Pinto M, $McFarland SA
17:40
Co-culture Mimic as a Tool to Understand Chemical Communication between Bacteria Liang LL, Sproule AS, Haltli BH, Marchbank DM, Overy DO, Burrue FB, Duncan ND, Lanteigne ML, Correa HC, *Kerr RK
17:40
Discovery of an Anticancer Polyether Natural Product from Kitasatospora sp. RKND004 Isolated from PEI Soil Sproule A, Berrue F, Correa H, Haltli B, $Kerr RG
17:40
Pathway Determination in Anaerobic Bacteria using Uniformly Labeled Glutamate and 13C NMR Spectroscopy *McDonald NC, $White RL
17:40
Anti-cancer Methods and Applications of Small Molecule and Peptide-drug Conjugates Papatzimas JW, Gorobets E, Maity R, *Bahlis NJ, $Derksen DJ
17:40
19F-labeled b-phosphoglucomutase for Transition State Analysis and the Synthesis and Evaluation of Inhibitors Ampaw A, $Jakeman DL
17:40
Developing Fluorogenic Catalytic DNA for Strain-specific Detection of Clostridium difficile Chang D, Shen Z, $Li Y
17:40
Temperature Dependent Natural Product Production in Marine Arctic Actinomycetes Gallant C, Haltli B, Kerr R
17:40
Synthesis and Kinetic Evaluation of Irreversible Inhibitors of Tissue Transglutaminase Akbar A, $*Keillor JW
17:40
Cystein-functionalization of an Antimicrobial Peptide Allows the Spontaneous Formation of a Dimer with a 30-fold Enhanced Antimicrobial Activity Thamri A, Letourneau M, Chatenet D, Castonguay A, Perreault J
17:40
Investigation of Peptides Exhibiting Affinity towards Advanced Materials Kim HSD, Monahan T, *Urquhart T, $Honek J
17:40
Conduritol Aziridines as 18F Labelled Positron Emission Tomography Probes for Imaging Glucocerebrosidase: A Biomarker for Parkinson's Disease Tesolin D, Esarik A, Wang S, Chowdhury M, $Phenix C
17:40
Development and Study of Fluorinated GW2580 Derivatives for Future Use as Radiotracers for PET Imaging of TRK and CSF-1R Choi S, *Bernard-Gauthier V, $Schirrmacher R
17:40
Developing a Simple, High-throughput Angiogenesis Assay Using Zebrafish Embryos $Sarty KI, Johnson JA, Martyniuk CJ, *Gray CA
17:40
Application of NMR Metabolomics in the Discovery of Natural Products Sproul MS, $*Gray CA, Johnson JA
17:40
Synthesis of Novel 4'-modified Nucleoside Analogues and their Properties in Oligonucleotides Malek-Adamian E, *Martinez SM, $Damha MJ
17:40
The Effects of Fermentation Conditions on the Biosynthesis of Natural Products by Endophytic Fungi $Fournier JE, Johnson JA, *Gray CA
17:40
Investigating the Permeability of Semi-peptidic Macrocycles Comeau C, Leclair G, $*Marsault E
17:40
Anticancer Drug Leads from Traditionally Used Canadian Medicinal Plants Bos A, Li H, Johnson JA, $*Gray CA, Jean S, Robichaud GA
17:40
Application of a Simple Bioactivity Profiling Strategy to Natural Product Discovery from Endophytes of Marine Macroalgae Flewelling AJ, Johnson JA, $*Gray CA
17:40
Recognition of "Minimal" Ligands by Enolase Superfamily Enzymes Aboushawareb S, $Bearne SL
17:40
Positional Impact of C8-aryl-deoxyguanosine Probes within the Thrombin Binding Aptamer and their Influence on Thrombin Binding Affinity Van Riesen AJ, *Manderville RA, Fadock KL, Deore PS
17:40
Synthesis and Biological Evaluation of Substituted Beta-alanines for the Treatment of Epilepsy Colaguori R, Stover KR, Stafford PM, Zhang L, $*Weaver DF
17:40
Characterization of Oxidized Fatty Acids from a Novel Marine Sediment-derived Bacterium Goldberg S, *Haltli B, $Kerr R
17:40
Design and Development of Novel STAT SH2 Domain Inhibitors Tin G, *Cumaraswamy A, $Gunning P
17:40
Synthesis of an Oxidatively Sensitive Fluorescent Analogue of Vitamin E Hildering A, *Atkinson J
17:40
Developing a Lead Compound for the Inhibition of Bacterial DNA Gyrase Khan U, $Weaver D
17:40
Soil Metagenomic Library Construction to Access Natural Product Biodiversity *Gosse JT, Hill P, $Boddy CN
17:40
How to Obtain High-precision Structural Information from Spin-labelled Proteins Balo AR, Feyrer H, $*Ernst OP
17:40
Investigation of Methylation and Reduction Events in the Biosynthesis of a Polymethylated Polyketide Larade S, Thuss JAJ, Gao Z, $Vederas JC
17:40
Molecular Probes for Cystic Fibrosis Research Junor P, $*Viirre RD
17:40
Inclusion Body Formation of Cu, Zn-superoxide Dismutase in Escherichia coli Simon H, Almey J, $Meiering EM
17:40
Synthesis of Novel Curcumin Analogs Alharbi SA, Mohapatra PP, $*Jha A, Cameron TS, Rupasinghe VHP
17:40
Synthesis of a Molecular Imaging Probe to Study Glutamate Receptors iGluR6 at Synaptic Connections Tian Z, Acton SL, Hinderle M, $*Menard F
17:40
Selectivity in Fungal Polyketide Thioesterases: Aromatic Cyclization as a Logic Gate for Pathway Termination Heberlig GW, Hansen F, Schmeing TM, $*Boddy CN
17:40
Inducing Production of Bioactive Cryptic Natural Products through Co-culture of Coral-derived Microbes MacIntyre LW, $Kerr RG
17:40
Design of Potential Selective Inhibitors for Thymidine Kinase from Variola virus $*Franca TCCF, Garcia DRG, Guimaraes APG, Ramalho TCR, Forgione PF
17:40
Exploring the Active Sites of Pseudomonas aeruginosa Pantothenate Kinase by Synthesizing Pantothenate Analogues Guan J, $*Auclair K
17:40
Temporal Patterning of Hydrogel Biochemical Environments to Mimic the Dynamic ECM Nijsure D, $Wylie RG
17:40
Consequences of Acidification and Unfolding Stress on the Fold and Zinc-binding Properties of Anthrax Lethal Factor Lo SY, $*Siemann S
17:40
Red Light Control of Ion Channel Blockers Collins CV, Dong MX, $Woolley GA
17:40
Chemical Synthesis of a Series of Estrane Derivatives with a Bromoethyl Side Chain at Position 3 *Lespérance M, Maltais R, Trottier M-C, $Poirier D
17:40
Structural and Kinetic Studies of PD-L1 Inhibition Hanley RP, $*Wulff JE, Hof F, Carr MD, An J, Horvath SW, Walker K, Powell D, Messmer D
17:40
A Comparison between the Application of NMR and LC-HRMS Based Metabolomics on the Discovery of Natural Products from Endophytic Fungi Clark TN, Johnson JA, $*Gray CA
17:40
A Stability Library of Silver and Gold Nanostructures for Applications in Biomedicine de Alwis Weerasekera H, *Silvero J, $Scaiano JC
17:40
Metabolic and Genetic Engineering of Escherichia coli for the Production of Complex Carbohydrates Hassan M, *Lundgren B, $Boddy CN, Whitfield D, Schoenhofen IC, Clark B
17:40
Discovery and Characterization of a Potent and Selective EP4 Receptor Antagonist *Schiffler MA, Chandrasekhar S, Fisher MJ, Harvey A, Kuklish SL, Wang X-S, Warshawsky AM, York JS, Yu X-P
17:40
Isolation, Preparation and Biological Properties of Soybean-flaxseed Protein Co-precipitates $*Alu'datt MH, Alli I
17:40
Development of Two Series of Potent and Selective CDK8 Inhibitors with Distinct Binding Modes *Bergeron P, Koehler MFT, Blackwood EM, Bowman K, Clark K, Kiefer JR, Maskos K, McCleland M, Orren L, Salphati L, Schmidt S, Schneider EV, Wu J, Beresini M
17:40
Using Positron Emission Tomography to Monitor Biodistribution of Radiolabelled Analogues of Enterolactone *Allen KJH, Petriew SC, Phenix CP, $Krol ES
17:40
Reversible Covalent Bonding of an Azobenzene Cross-linker to a Target Peptide Kachi-Terajima C, *Woolley GA
17:40
Synthesis, Characterization and Repair of Backbone Modified O6-2'-deoxyguanosine-alkylene-O6-2'-deoxyguanosine Intrastrand Cross-links O'Flaherty DK, $*Wilds CJ
17:40
Quantification of Brassinin Using Fluorescence Spectroscopy Pribytkova T, Schmidt K, $*Sorensen JL
17:40
One-pot Chemoenzymatic Synthesis of Rhamnose Biosynthesis Inhibitors McCormick NE, $*Jakeman DL
17:40
Expression and Characterization of STAT3/STAT5 Proteins for Assay Development of Small Molecule Inhibitors de Araujo ED, Kraskouskaya D, $*Gunning PT
17:40
Continuous Flow Halogenation: Challenges and Opportunities Gunn D, $Kocsis L, *Sip?cz T, Jones R, Darvas F
17:40
Discovery of DLK Inhibitors for the Treatment of Neurodegenerative Diseases *Huestis MP
17:40
Design and Synthesis of Monobactam Analogues for the Inhibition of NDM-1 Pena D, $*Boudreau M
17:40
Status of Serum Trace Elements - Copper, Manganese and Zinc in Preeclamptic Pregnant Women of Riyadh, Saudi Arabia *Noura A, Hajera T
17:40
Design and Synthesis of Lasso-inspired Peptides with Distinct Antibacterial Mechanisms $*Bédard F, Hammami R, Gomaa A, Suribade M, Fliss I, Biron E
17:40
Ru(II) Dyads that Incorporate a-oligothiophenes: Modular and Versatile Photosensitizers for PDT *Monro S, Shi G, Hennigar R, Colpitts J, Yin H, DeCoste R, Spencer C, Chamberlain L, $McFarland SA
17:40
Novel Bioactive Natural Products from Medicinally Important Plants Khan M, Rodriguez E, $*Ata A
17:40
Birch Bark - A Renewable Resource for Betulin and its Derivatives $*Bierenstiel M, Sleem H
17:40
A Mild and Fully Automated GMP Production of 11C-labeled (+)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol ([11C]-(+)-PHNO) $*Hicks JH, Kovacs MS
17:40
Synthesis and Properties of New BODIPY Derivatives for 5¢-end Labelling Oligonucleotides Deore PS, $*Manderville RA
17:40
Investigation of DIBI, an Fe-binding Polymer ­ Determination of the Activation Energy of Ligand Exchange $*Bierenstiel M, Ang MTC, Holbein BE
17:40
The Use of Cucurbiturils in Drug Formulations for Alleviation of Adverse Toxicities $*Wang R, Li S, Yang X, Chan J, Lee S
17:40
Transitions in Spider Wrapping Silk Conformation and Dynamics Probed by 19F-NMR Spectroscopy *Sarker M, Orrell KE, Xu L, Tremblay M-L, Liu X-Q, $Rainey JK
17:40
Isolation of Antifungal Compounds from Plant-ant Associated Actinobacteria *Centko RM, Currie CR, $Clardy J
Wednesday AM
BM5
203
Medicinal Chemistry: A Canadian Tradition - Joint with OR
Organizer(s) - Jason Burch and Patrick Gunning
Chair(s) - Jason Burch and Patrick Gunning
08:00
Copper-catalyzed Oxidative Decarboxylative a-arylation with Arylboron Reagents Moon PJ, Yin S, $Lundgren RJ
08:20
Phosphorus-containing Heterocyclic Compounds as Tools for Drug Discovery and Catalysis $*Tsantrizos YS
09:00
From Aryl Iodides to 1,3-dipoles: Design of Palladium Catalyzed Multicomponent Approaches of Nitrogen Heterocycles Tjutrins J, Martin Torres G, $*Arndtsen BA
09:20
Discovery of CFTR Modulators for the Treatment of Cystic Fibrosis *Bear BR
10:00
 
Coffee Break
10:20
SPECT Evaluation of 1-methylpiperidin-4-yl 4-iodobenzoate, a Butyrylcholinesterase Diagnostic Radioligand for Alzheimer's Disease $*Darvesh S, DeBay DR, Reid GA, Martin E, Bowen CV, Pottie IR
10:40
Design and Development of Agents Targetting Both Proteopathy and Immunopathy in Alzheimer's Disease Kelly B, Diez-Cecilia E, Sweeting B, Pan L, Barden C, *Weaver D
11:20
 
End of Session
BM8
202
Topics in Chemical Biology
Organizer(s) - Andrew Woolley
Chair(s) - Andrew Woolley
08:00
ME47, a Minimalist Protein Designed to Target the Myc/Max:E-box DNA Network, Decreases Cancer Cell Growth in vivo $*Shin JA
08:20
Recent Advances in Catalomics $*Yao S
09:00
Fluorogenic Protein Labelling in Living Cells $*Keillor JW, Chen Y, Tsao K
09:20
Genetically Encoded Discovery of Functional Ligands $*Derda R
10:00
 
Coffee Break
10:20
Selective, Promiscuous, Specific, Pan-specific... New Chemical Tools for Research on Protein Methyation Pathways Hof F
11:00
Safe and Effective Hemoglobin-based Oxygen Carriers: The NO Problem vs. CuAAC and a Surprising Biotin-avidin Alternative $*Kluger R, Singh S, Wang A, Roberts M
11:20
 
End of Session
Wednesday PM
BM2
203
Carbohydrates - Joint with OR
Organizer(s) - David Jakeman
Chair(s) - David Jakeman
14:00
Glycosylation by Phosphorylases and Glycosyltransferases: Mechanistic Aspects and Application for Synthesis $*Nidetzky B
14:40
A Role for Underlying Glycan Structure in Influenza Binding: Extending the Species Specificity Paradigm Grant OC, Hadden JA, Ye J, Smith HMK, Peng W, De Vries R, McBride R, Paulson JC, $*Woods RJ
15:20
Tunable Monoacylation of Methylglucoside Using Boronic Ester-based Transient Directing-protecting Groups (TDPGs) Rocheleau S, $*Moitessier N
15:40
Development of Chemical Tools for Monitoring and Inhibition of O-GlcNAc Transferase Activity Alteen MG, Tan HY, Eskandari R, $*Vocadlo DJ
16:00
 
End of Session
BM6
200C1
Structure, Dynamics and Implications of Multi-state Biomolecules
Organizer(s) - Scott Prosser and Jan Rainey
Chair(s) - Scott Prosser
14:00
Structure, Dimerization, and Cholesterol Binding of the Amyloid Precursor Protein Transmembrane C99 Domain and Amyloidogenesis $*Sanders CR
14:40
Discover Major Conformational Motions from Misfolding of Amyloid-b Peptide Lu S, Hleap JS, Blouin C
15:00
Chemical Approaches to Probe and Modulate Amyloid Assembly of Natively Unfolded Polypeptides Nguyen PT, Quittot N, $*Bourgault S
15:20
Monitoring Coacervation of an Elastin-like Protein Using NMR Spectroscopy $*Sharpe S, Reichheld SE, Keeley FW
16:00
 
Coffee Break
16:20
Implications of Intrinsic Disorder in Spider Wrapping Silk Tremblay M-L, Xu L, Sarker M, Orrell KE, Liu X-Q, $*Rainey JK
16:40
Reassessing Drug Targets in Alzheimer's Disease Using Comprehensive Kinetic Modeling Walsh R
17:00
Protein Misfolding and Prion-like Propagation in Neurodegenerative Disease: Connecting Theory, Experiment, and Therapy $*Plotkin SS
17:40
 
End of Session
BM8
202
Topics in Chemical Biology
Organizer(s) - Andrew Woolley
Chair(s) - Andrew Woolley
14:00
Studying RNA Silencing Using the Viral Suppressor Protein p19, Small Molecules, and Expanded Genetic Codes $*Pezacki JP, Danielson DC, Powdrill M
14:40
Genetically Encoded Protein Phosphorylation $*O'Donoghue P
15:20
Organotellurium Probes for Multiparameter Biology at Cellular Resolution Edgar LJ, Willis LM, Park H, $*Nitz M
16:00
 
Coffee Break
16:20
Development of Bioorthogonal Chemistry Tools for Studying Class B GPCRs $*Lin Q, Ramil C, An P, Yu Z
17:00
Laser-guided Munition in the Click-chemistry Arsenal: Light-induced SPAAC, Michael, and Diels-Alder Ligation Techniques $*Popik V
17:20
Molecular Probes to Study the Ca2+ Signaling Cascade in Astrocytes $*Menard F
17:40
 
End of Session
BM4
200C2
General Biological and Medicinal Chemistry
Organizer(s) - Stephen Bearne
Chair(s) - Stephen Bearne, David Jakeman
14:00
 
Bernard Belleau Award Lecture
14:00
Targeted Covalent Modification of Cancer Promoting Proteins: Lessons Learned $Gunning PT
14:40
Design of a Pointsource Heterogeneous Photosensitizer Device for Improving Photodynamic Therapy for Cancer Treatment Ghosh G, Minnis M, Ghogare AA, Abramova I, Cengel K, Busch T, Greer A, $McFarland S
15:00
Improved Photosensitizers and Light Delivery Protocols for Melanoma PDT Yin H, $McFarland SA
15:20
Chitosan Derivatives for Wound Healing *Mutus B, Fontana K, $Tellios V, Hutnik C
15:40
Ruthenium-based Organometallic Therapeutics and Development of Novel Strategies for their Thermoresponsive Targeted Delivery $*Castonguay A, Golbaghi G, Haghdoost M
16:00
 
Coffee Break
16:20
Prodrug-inspired Substrates Employing Lysosomotropic Reporter Groups for PET Imaging Cathepsins Vigliarolo BG, Chowdhury MA, Wang S, Moya IA, $Phenix CP
16:40
Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-resistant Staphylococcus aureus and Its Abrogation by Small Molecules $*Boudreau MA, Fishovitz J, Llarrull LI, Xiao Q, Mobashery S
17:00
A PIK-targeting Activity-based Probe Can Detect Changes to Protein-protein Interactions during Hepatitis C Replication Desrochers GF, Sherratt AR, Cornacchia C, $*Pezacki JP
17:20
Development of a SPR Immunosensor for Monitoring Silent Hypersensitivity to L-asparaginase during Chemotherapy for Leukemia Charbonneau D, Aubé A, Breault-Turcot J, Rachel N, Guerrero V, Delorme K, Masson J-F, $*Pelletier J
17:40
 
End of Session
Thursday AM
BM5
203
Medicinal Chemistry: A Canadian Tradition - Joint with OR
Organizer(s) - Jason Burch and Patrick Gunning
Chair(s) - Jason Burch and Patrick Gunning
08:00
Identification of Potent and Selective Bromodomain Inhibitors to Probe Physiological Function Magnuson S
08:40
Peptidic Inhibitors for Epigenetic Reader Proteins of the Polycomb Family - Inhibiting Master Regulator Proteins Upregulated in Stem-like Cancers Milosevich N, Gignac M, Simhadri C, Li J, Horvath S, Anderson C, Croft C, Warmerdam Z, $Hof F
09:00
Discovery of AMG 337, a Potent and Selective Inhibitor of MET with High Unbound Exposure and Robust In Vivo Antitumor Activity *Boezio AA
09:40
Synthesis and Evaluation at the Delta Opioid Receptor of Analogues of Leu Enkephalin with Improved Pharmacokinetics *Beaudeau J-L, Blais V, Guérin B, Gendron L, $Dory YL
10:00
 
Coffee Break
10:20
Medicinal Chemistry of Ghrelin Analogues for Molecular Imaging $*Luyt LG
11:00
Targeting Protein-protein Interaction for New Cancer Therapeutics: From Discovery to Clinical Development $*Wang S
11:40
Synthetic Proteomimicry in Cancer Research $Fletcher S, Chen L, Lanning ME, *Yap JL
12:20
 
End of Session
BM6
200C1
Structure, Dynamics and Implications of Multi-state Biomolecules
Organizer(s) - Scott Prosser and Jan Rainey
Chair(s) - Jan Rainey
08:00
Addition of Negative Charge through Mutation of an Evolutionarily Conserved Tyrosine Residue Induces Global, Concerted Millisecond Timescale Dynamics in the Intrinsically Disordered Carboxyl Terminus of Gamma-tubulin Harris J, Oliver CG, Vogel J, $*Mittermaier A
08:40
Noncovalent Loading of Vinblastine on Single-walled Carbon Nanotubes: A Study from Drug Mechanism of Action to its Delivery $*Alisaraie L, Li Z, Tozer T
09:00
Targeting Tau Protein Biochemistry via Epitope-based Approach $*Martic S
09:20
Maturation and Misfolding of Cu,Zn Superoxide Dismutase $*Meiering EM, Broom HR, Doyle CM, Rumfeldt JA, Sekhar A, Kay LE
10:00
 
Coffee Break
10:20
The Role of Dynamics and Dimer Asymmetry in Catalysis. An NMR and Time-resolved X-ray Diffraction Study of Fluoroacetate Dehalogenase $*Prosser RS, Kim TH, Mehrabi P, Pai E, Sljoka A
10:40
Interactions between U24 from HHV-6A and 7 and Nedd4 or Smurf2 WW Domains Sang Y, Zhang R, Scott WRP, Creagh AL, Haynes CA, $*Straus SK
11:00
Structural Analysis of Disordered Chibby in Wnt/b-catenin Signaling Pathway Killoran RC, Sowole MA, Konermann L, Shilton BH, Choy WY
11:20
Targeting Methylated Peptides Using Highly Functionalized p-sulfonato Calix[4]arenes as a Biomimic Shaurya A, Daze K, Garnett G, Starke M, Li J, Henderson T, Kenny J, $Hof F
11:40
Protein Regulatory Switches $*Gsponer J
12:20
 
End of Session
Thursday PM
BM6
200C1
Structure, Dynamics and Implications of Multi-state Biomolecules
Organizer(s) - Scott Prosser and Jan Rainey
Chair(s) - Charles Sanders
14:00
Structure, Dynamics, and Energy Landscapes of G Protein-coupled Receptors Explored by Enhanced Molecular Dynamics Simulations $*Filizola M
14:40
Activation of the A2A Adenosine G Protein-coupled Receptor by Conformational Selection Ye L, Eps NV, Zimmer M, Ernst O, $Prosser S
15:00
Modulating the Structure of Apelin to Bias Signalling of the APJ Receptor: Impact and Potential in Cardiovascular Diseases $*Marsault E, Murza A, Trân K, Coquerel D, Sainsily X, Côté J, Besserer-Offroy E, Dumaine R, Auger-Messier M, Lesur O, Longpré JM, Sarret P
15:20
The Identification and Characterization of an Endoprotease Involved in the Degradation of Mammalian Peptide Hormone Apelin McKinnie SMK, Fischer C, Mosquera F, Vederas JC
15:40
Elucidating Membrane-induced Modulation of Proprotein Conformation and Dynamics Shin K, Sarker M, Huang SK, Anini Y, $*Rainey JK
16:00
 
Coffee Break
16:20
Activation of the E3 Ubiquitin Ligase Parkin Using Multiple Protein Interactions Aguirre JD, Condos TEC, Spratt DE, Barber KR, $*Shaw GS
16:40
Computational Design of Dynamics into a Stable Globular Protein Davey JA, Damry AM, Goto NK, $*Chica RA
17:00
Drug Discovery Implications of Protein Dynamics when Progressing Hits Farrow NA
17:40
 
End of Session
BM4
203
General Biological and Medicinal Chemistry
Organizer(s) - Stephen Bearne
Chair(s) - Stephen Bearne, David Jakeman
14:00
Ion Transport and Bacteriological Properties of Binol-functionalized Synthetic Transporters Hébert A, Vidal M, $Schmitzer AR
14:20
Biomaterials to Study and Control Cell-matrix Interactions, and Inhibit Cytokines for Anti-angiogenic Therapies $*Wylie RG, Lambert C, Nijsure D, Huynh V
14:40
Discovery of Metabolically Stable Covalent Inhibitor of mTOR Signalling *Park JS, Geletu M, Berger A, Rosa D, $Gunning PT
15:00
Biodegradable Gold Nanoshells for Combinatory Treatment of Cancer Curry DE, Servsos MR, Jiang R, Zhang X
15:20
Towards New Approaches to Treat Bacterial Infections: Small Molecule Targets Evasion Mechanism of Salmonella enterica to Restore its Itaconate Sensitivity Hammerer F, Chang JH, Castañeda Ruiz A, $Auclair K
15:40
Considering the STAT3 Alkylating Potential of the Small Molecule Inhibitor S3I-201 Ball DP, $*Gunning PT, Lewis AM, Williams D, Resetca D, Wilson DJ
16:00
 
Coffee Break
16:20
Rapid F-18 Labeling of Polymer Nanoparticles for in-vivo Applications Berke S, Bailey J, Kampmann L, Glowacki B, Jurkschat K, Weberskirch R, $Schirrmacher R
16:40
Synthesis and Biological Evaluation of a New Noscapine Analogue Ghaly PE, Abou El-Magd R, Churchill CDM, Tuszynski JA, *West FG
17:00
Cyclic Dinucleotides as Mucosal Vaccine Adjuvants and their Roles in Bacterial Biofilm Formation *Yan T
17:20
 
End of Session